Buy Clomid Online UK

Without Prescription

Doctor's Analysis of Clomiphene’s Properties


Clomiphene is a very old-fashioned infertility medicine that's been around for many decades and is used mainly for women. It's been used classically in the recreational and professional anabolic steroid bodybuilding world for PCT. It's also used for male infertility, associated with anabolic steroid induced hypogonadism. And, of course, it's used as a sole agent for TRT.

The history of Clomiphene starts in 1956 with a team of scientists at Merle Chemical Company, where they developed this compound. In 1961 they started doing human trials on women that had infertility secondary to problems ovulating, because this medicine increased ovulation. Several years later, in the middle 60-s, they realized that this would also work for male subjects. So, they tested on men, and they found that it increased both LH and FSH and led to increased sperm count.

This compound is the most commonly prescribed infertility medicine mainly for men and women since the 1960's.

Mechanism of Action of Clomiphene

This is a classical selective estrogen receptor modulator, a tri-phenyl methylene compound that is a synthetic estrogenic chemical. It has both the actions throughout the body in different tissue sites and inhibitory actions. That's why it's a receptor modulator. That's what that means: in the hypothalamus it acts as an anti-estrogen, interfering with normal estrogenic negative feedback, resulting in increased pulsatile release of the hormone from the hypothalamus, stimulating subsequently an increase in LH and FSH. From that point, obviously, it's going to hit the gonads and have them this effect.

Medical uses Classically for Clomiphene

Number one is infertility for women. It's interesting that male infertility has never been studied well, unlike that for the women. And it only works for some men. So, the failure for men has to occur somewhere in the hypothalamus or pituitary for this agent to work. It will not work if they have a primary failure in the testes site.

Doctor's Analysis of Clomiphene’s Properties

It’s very interesting that in the last 10 years or so some doctors used this agent for men for low testosterone states. Now, I have to differentiate something very important that I've discovered, and other physicians and experts and people in the world that are involved in this type of work have realized this too. That men that have used anabolic steroids as a history have been exposed their central nervous systems have been exposed to steroids, when they use this compound either in PCT or classically for TRT long term, they feel horrible. They have poor mood response, despite on paper increasing testosterone and, of course sperm counts. So, we have to differentiate that. The man that used steroids in the past most commonly does poorly as a sole agent.

Men that have not had prior exposure, that have low TRT from organic causes, this agent can work for them. I want that that note to be known very carefully, that it's not used well for men for TRT only their prior steroid exposure, but it could be used even for years. I have some experience to have been doing very well in this agent for years.

Classic Effect in the Bodybuilding World for PCT

The historical notes have used this drug, and there are so many renditions and variations of this type of classic PCT. Typically, there are three drugs: human chorionic gonadotropin, Tamoxifen, which is actually another type of selective estrogen receptor modulator and Clomiphene.

So, in this type of classic PCT you have two SERMs that are being used. And again, there’re so many variations on this why this is the shorter and the least used of the services Tamoxifen. This Clomiphene is used for a short period about 30 days. And why is it used? Why is it a shorter acting time than Tamoxifen longer-acting? It's a stronger stimulatory agent for LH and FSH in the central nervous system. It also can lead to paradoxically increased estrogen systemic levels in the body. So, Tamoxifen is, probably, a better agent to use long term and during the continuation period for PCT, because it's really more anti estrogenic in the periphery for gynecomastia. There it is. And it's a softer stuck down. That's why these two SERMs are used classically with the PCT regimen now. There's no data for this. That's why I'll be working on this in research.

The other effect used more in a modern fashion for Clomiphene and above steroid-induced hypogonadism. Now we have experts using this drug again, sometimes erroneously, as a sole agent. Currently there have been some papers coming out by other experts in America saying that this is a good drug to add on to HCG. So, man is using steroids comes off withdrawal period, we have to help him, there are different agents we can use. Human chorionic gonadotropin is certainly one of them. When he's on HCG, you can use more for fertility, though, small doses of Clomiphene, if the HCG itself is not working over this period to rest with a man.

This is novel and this is new, and we have no data for this, but this is the new utility we're seeing. We're seeing Clomiphene as an add-on agent with HCG for anabolic steroid induced hypogonadism, and it’s very interesting.

See Also